Medisepte - COLLEASE+
COLLEASE+
COLLEASE+ is a next-generation freeze-dried type I atelocollagen, extracted from horse collagen using a patented purification method without proteolytic enzymes. This advanced process preserves the collagen’s natural structure, ensuring high bioactivity, excellent biocompatibility, and non-immunogenic performance without the need for cross-linking.
Key Benefits
Stimulates new fibroblast production
Enhances natural collagen regeneration
Improves skin firmness, thickness, and elasticity
Reduces fine lines, wrinkles, and sagging
Delivers natural results without volume increase
Suitable for all ages, including preventive treatments
Advanced Formula
Type I Atelocollagen – biostimulator with dual action (stimulation + bioregeneration)
Vitamin C – supports collagen synthesis
Glutathione – antioxidant protection
Indications
Skin regeneration and tissue reconstruction
Reduction of wrinkles and skin laxity
Treatment of scars
Improvement of skin elasticity and firmness
Thin, flabby, atrophic, or finely wrinkled skin
Areas of Application
Face
Neck
Décolleté
Hands
Eye and mouth contour
Any area with thin or sagging skin
Expected Results
Firmer, tighter, and denser skin
Improved skin quality and texture
Reduction of fine wrinkles and sagging
Natural, discreet, and long-lasting rejuvenation
Method of Application
Prepare a suspension using 200 mg collagen per 10 ml activator
Mix until a homogeneous solution is obtained
Administer via intradermal injection using 30G/4mm or 32G/4mm needles
Optional: up to 0.5 ml lidocaine may be added
Product must be used in one session only
Recommended Dosage
Face: 3.5 ml
Neck: 1.5 ml
Décolleté: 3 ml
Hands: 2 ml (1 ml per hand)
Treatment Protocol
4 treatment sessions at 2–4 week intervals
1 follow-up session after 6 months
Safety & Tolerability
Possible temporary reactions include mild swelling, redness, itching, soreness, bruising, or small nodules in case of superficial injection. These effects typically resolve spontaneously within a few days.